This conference, taking place February 28-March 4, 2022, will allow in-person discussions of the results and future opportunities in studying galactic ecosystems with FIR and sub-mm wave methods, using SOFIA, ALMA and other platforms. A specific goal is to explore synergy between observatories, including SOFIA, ALMA, JWST, and with theory. Registration is now open on the conference website. Registration fees include room and board at the UCLA Lake Arrowhead Lodge, in the majestic mountains of the San Bernardino National Forest.